top of page


Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration. 

Law, A.-L., Jalal, S., Pallett, T., Mosis, M., Guni, A., Brayford, S., Yolland, L., Marcotti, S., Levitt. J.A., Poland, S.P., Rowe-Sampson, M., Jandke, A., Köchl, R., Pula, G., Ameer-Beg, S.M., Stramer, B.M., and Krause, M. (2021) Nature Communications, 12(1): 5687; DOI: 10.1038/s41467-021-25916-6

Lamellipodin-Rictor signaling mediates glioblastoma cell invasion and radiosensitivity downstream of EGFR.

Moritz, S., Krause, M., Schlatter, J., Cordes, N., and Vehlow, A. (2021) Cancers, 13(21): 5337; DOI: 10.3390/cancers13215337

Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation.

Brazzo, J.A., Biber, J.C., Nimmer, E., Heo, Y., Ying, L., Zhao, R., Lee, K., Krause, M., and Bae, Y. (2021)  134(12), DOI: 10.1242/jcs.257709

Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation.

Dimchev, G., Amiri, B., Humphries, A.C., Schaks, M., Dimchev, V., Stradal, T.E.B., Faix, J., Krause, M., Way, M., Falcke, M., and Rottner, K. (2020) J. Cell Science, 133, jcs239020. DOI:10.1242/jcs.239020

FBP17 and CIP4 recruit SHIP2 and Lamellipodin to prime the plasma membrane for Fast Endophilin-Mediated Endocytosis.

Wah Hak, L.C., Khan, S., Di Meglio, I., Law, A.-L., Häsler, S.L.A., Quintaneiro, L., Ferreira, A., Krause, M., McMahon, H., and Boucrot, E. (2018). Nature Cell Biology, 20, 1023-1031.

Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice. 

Bodo, C., Fernandes, C., and Krause M. (2017) Scientific Reports, 7:5365, DOI:10.1038/s41598-017-05043-3

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Carmona, G., Perera U., Gillett C., Naba A., Law A., Sharma V.P., Wang J., Wyckoff J., Balsamo M., Fuad Mosis F., De Piano, M., Monypenny, J., Woodman, N., McConnell, R.E., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., Hynes, R.O., Gertler, F.B., and Krause M. (2016) Oncogene, 

doi: 10.1038/onc.2016.47

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.

Krause, M. and Gautreau, A. (2014) Nature Reviews Molecular Cell Biology, 15, 577-90.

Lamellipodin and the Scar/WAVE complex cooperate to regulate cell migration 

Law, A., Vehlow, A., Kotini, M., Dodgson, L., Soong, D., Theveneau, E., Bodo, C., Taylor, E., Navarro, C., Perera, U., Michael, M., Dunn, G.A., Bennett, D., Mayor, R., and Krause M. (2013) Journal of Cell Biology, 203(4), 673-689. 

Endophilin, Lamellipodin, and Mena Cooperate to Regulate F-actin-dependent Endocytosis of the EGF-receptor.

Vehlow, A., Soong, D., Vizcay-Barrena, G., Bodo, C., Law, A., Perera, U., and Krause, M. (2013) EMBO J 32, 2722-2734.  

c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.

Michael, M., Vehlow, A., Navarro, C., Krause, M. (2010) Curr Biol, 20(9), 783-91.

Drosophila Pico and its mammalian ortholog Lamellipodin activate serum response factor and promote cell proliferation.

Lyulcheva E. Taylor E. Michael M., Vehlow A., Tan S., Fletcher A., Krause M, Bennett D., (2008) Dev Cell 15, 680-690.

bottom of page